Critical periods for experience-dependent synaptic scaling in visual cortex

  title={Critical periods for experience-dependent synaptic scaling in visual cortex},
  author={Niraj S. Desai and Robert H. Cudmore and Sacha B. Nelson and Gina G. Turrigiano},
  journal={Nature Neuroscience},
The mechanisms underlying experience-dependent plasticity and refinement of central circuits are not yet fully understood. A non-Hebbian form of synaptic plasticity, which scales synaptic strengths up or down to stabilize firing rates, has recently been discovered in cultured neuronal networks. Here we demonstrate the existence of a similar mechanism in the intact rodent visual cortex. The frequency of miniature excitatory postsynaptic currents (mEPSCs) in principal neurons increased steeply… CONTINUE READING
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