Critical period revisited: impact on vision

@article{Morishita2008CriticalPR,
  title={Critical period revisited: impact on vision},
  author={Hirofumi Morishita and Takao K. Hensch},
  journal={Current Opinion in Neurobiology},
  year={2008},
  volume={18},
  pages={101-107}
}

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References

SHOWING 1-10 OF 86 REFERENCES
Critical period plasticity in local cortical circuits
  • T. Hensch
  • Biology
    Nature Reviews Neuroscience
  • 2005
TLDR
The reactivation of this process, and subsequent recovery of function in conditions such as amblyopia, can now be studied with realistic circuit models that might generalize across systems.
Critical period regulation.
  • T. Hensch
  • Biology, Psychology
    Annual review of neuroscience
  • 2004
TLDR
This review summarizes the current understanding of known critical periods across several systems and species and delineates a number of emerging principles: functional competition between inputs, role for electrical activity, structural consolidation, regulation by experience, special role for inhibition in the CNS, potent influence of attention and motivation, unique timing and duration.
Experience-Driven Plasticity of Visual Cortex Limited by Myelin and Nogo Receptor
Monocular deprivation normally alters ocular dominance in the visual cortex only during a postnatal critical period (20 to 32 days postnatal in mice). We find that mutations in the Nogo-66 receptor
Inhibitory threshold for critical-period activation in primary visual cortex
TLDR
It is shown that the potential for plasticity is retained throughout life until an inhibitory threshold is attained, and a threshold level of inhibition within the visual cortex may trigger, once in life, an experience-dependent critical period for circuit consolidation, which may otherwise lie dormant.
Critical periods during sensory development
Experience-dependent recovery of vision following chronic deprivation amblyopia
TLDR
It is demonstrated that complete visual deprivation through dark exposure restores rapid ocular dominance plasticity in adult rats and the loss of visual acuity resulting from chronic monocular deprivation is reversed if dark exposure precedes removal of the occlusion in adulthood, suggesting a potential use for dark exposure in the treatment of adult amblyopia.
Multiple periods of functional ocular dominance plasticity in mouse visual cortex
TLDR
Arc induction is used to monitor the functional pattern of ipsilateral eye representation in cortex during normal development and after visual deprivation, and functionally assessed OD can be altered in cortex by ocular imbalances substantially earlier and far later than expected.
Lifelong learning: ocular dominance plasticity in mouse visual cortex
...
...