Critical period plasticity and sensory function in a neuroligin-3 model of autism


Extensive experience-dependent refinement of cortical circuits is restricted to critical periods of plasticity early in life. The timing of these critical periods is tightly regulated by the relative levels of excitatory and inhibitory (E/I) neurotransmission during development. Genetic disruption of synaptic proteins that normally maintain E/I balance can… (More)


23 Figures and Tables