Critical period for retinoic acid-induced developmental abnormalities of the vitreous in mouse fetuses.

@article{Ozeki1999CriticalPF,
  title={Critical period for retinoic acid-induced developmental abnormalities of the vitreous in mouse fetuses.},
  author={Hironori Ozeki and Shoichiro Shirai and Kazuhiko Ikeda and Yuichiro Ogura},
  journal={Experimental eye research},
  year={1999},
  volume={68 2},
  pages={223-8}
}
To elucidate the underlying developmental mechanisms of persistent hyperplastic primary vitreous (PHPV) in humans, we investigated a mouse model for PHPV induced by retinoic acid. We treated C57BL/6NJcl mice at various stages of pregnancy (gestation days 7, 8, 9, 10, 11, or 12) with the teratogen retinoic acid, which affects the migration of neural crest cells. Untreated pregnant mice served as a control group. The eyes of the fetuses were examined histologically on day 18 on gestation… CONTINUE READING

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