Critical parameters in the MCF-7 cell proliferation bioassay (E-Screen).

  title={Critical parameters in the MCF-7 cell proliferation bioassay (E-Screen).},
  author={Thomas H\oj Rasmussen and Jesper Bo Nielsen},
  journal={Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals},
  volume={7 4},
The MCF-7 cell proliferation bioassay has grown in popularity as a rapid test for detecting potentially oestrogenic compounds. Several MCF-7 cell sublines with different sensitivities to oestrogens are currently used, with maximal proliferation responses ranging from two- to 10-fold above those of hormone-free controls. In the highly responsive MCF-7 BUS cell line, we evaluated critical assay parameters for test performance, including growth conditions, initial seeding densities and differences… CONTINUE READING

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