Critical oxygen tension in rat brain: a combined (31)P-NMR and EPR oximetry study.

  title={Critical oxygen tension in rat brain: a combined (31)P-NMR and EPR oximetry study.},
  author={Ellis L. Rolett and Ali Azzawi and K. J. Liu and Martin Yongbi and Harold M. Swartz and Jeff F. Dunn},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={279 1},
  • E. RolettA. Azzawi J. Dunn
  • Published 1 July 2000
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
The relationship between cerebral interstitial oxygen tension (Pt(O(2))) and cellular energetics was investigated in mechanically ventilated, anesthetized rats during progressive acute hypoxia to determine whether there is a "critical" brain Pt(O(2)) for maintaining steady-state aerobic metabolism. Cerebral Pt(O(2)), measured by electron paramagnetic resonance oximetry, decreased proportionately to inspired oxygen fraction. (31)P-nuclear magnetic resonance measurements revealed no changes in P… 

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