Critical overexpression of thrombospondin 1 in chronic leg ischaemia.

  title={Critical overexpression of thrombospondin 1 in chronic leg ischaemia.},
  author={Judith Favier and St{\'e}phane Germain and Joseph Emmerich and Pierre Corvol and Jean-Marie Gasc},
  journal={The Journal of pathology},
  volume={207 3},
The aim of this study was to identify gene expression governing the balance of angiogenic and angiostatic factors in human ischaemic leg tissues. In situ hybridization was used to screen for the expression of angiogenesis-related genes in tissues from 13 amputated limbs from patients suffering from critical leg ischaemia. The authors tested for mRNA of hypoxia-inducible transcription factors 1 alpha and 2 alpha, vascular endothelial growth factor, and its receptors VEGFR-1 and -2, the… CONTINUE READING


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