Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration.

@article{Rouaux2003CriticalLO,
  title={Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration.},
  author={Caroline Rouaux and Natasa Jokic and Corinne Mbebi and St{\'e}phanie Boutillier and J. -P. Loeffler and Anne-Laurence Boutillier},
  journal={The EMBO journal},
  year={2003},
  volume={22 24},
  pages={6537-49}
}
By altering chromatin structure, histone acetyltransferases (HATs) act as transcriptional regulators. We observed in a model of primary neurons that histone acetylation levels decreased at the onset of apoptosis. The CREB-binding protein (CBP) is a HAT of particular interest because it also acts as a co-activator controlling, among others, CREB-dependent transcriptional activity. It has been demonstrated that CREB exerts neuroprotective functions, but the fate of CBP during neuronal apoptosis… CONTINUE READING
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