Critical issues in benchmark calculations from continuous data.

  title={Critical issues in benchmark calculations from continuous data.},
  author={Kenny S. Crump},
  journal={Critical reviews in toxicology},
  volume={32 3},
The benchmark dose (BMD) is a dose that causes a specified low level of additional risk and is estimated using a statistical dose-response analysis. Regulatory agencies are using a statistical lower bound on the BMD in the place of the NOAEL for establishing exposure limits. However, there are still several issues regarding the BMD for which no clear consensus has emerged, particularly with respect to calculation of BMD from continuous response data. These include: (1) how to define the BMD… CONTINUE READING