Critical involvement of the hinge region of the follicle-stimulating hormone receptor in the activation of the receptor.

@article{Agrawal2009CriticalIO,
  title={Critical involvement of the hinge region of the follicle-stimulating hormone receptor in the activation of the receptor.},
  author={Gaurav L. Agrawal and Rajan R. Dighe},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 5},
  pages={2636-47}
}
The follicle-stimulating hormone receptor (FSHR) is a G-protein-coupled receptor with a large hormone-specific extracellular domain (amino acids (aa) 1-366) and a characteristic seven-transmembrane domain (TMD; aa 367-695). The extracellular domain is composed of leucine-rich repeats (LRRs; aa 18-259) connected to TMD by a hinge region (HinR; aa 260-366), whose role in the hormone action is not clearly understood. We generated a novel polyclonal HinR antibody that specifically stimulates cAMP… CONTINUE READING
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