Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia.

@article{Santini2007CriticalIO,
  title={Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia.},
  author={Emanuela Santini and Emmanuel Valjent and Alessandro Usiello and Manolo Carta and Anders Borgkvist and Jean-Antoine Girault and Denis Herv{\'e} and Paul Greengard and Gilberto Fisone},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 26},
  pages={6995-7005}
}
The molecular basis of L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID), one of the major hindrances in the current therapy for Parkinson's disease, is still unclear. We show that attenuation of cAMP signaling in the medium spiny neurons of the striatum, achieved by genetic inactivation of the dopamine and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), reduces LID. We also show that, in dyskinetic mice, sensitized cAMP/cAMP-dependent protein kinase/DARPP-32 signaling leads to… CONTINUE READING
Highly Influential
This paper has highly influenced 32 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 175 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 45 references

nesia in hemiparkinsonian mice

  • G Paxinos, C Watson
  • Biol Psychiatry
  • 1982
Highly Influential
2 Excerpts

Parkinson’s disease

  • N Pavon, AB Martin, A Mendialdua, R Moratalla
  • 2006
2 Excerpts

Similar Papers

Loading similar papers…