Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis.

@article{Ndhlovu2001CriticalIO,
  title={Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis.},
  author={Lishomwa C Ndhlovu and Nobuya Ishii and Kaoru Murata and Tateo Sato and Kazuo Sugamura},
  journal={Journal of immunology},
  year={2001},
  volume={167 5},
  pages={
          2991-9
        }
}
OX40 ligand (OX40L) expressed on APCs, and its receptor, OX40 present on activated T cells, are members of the TNF/TNFR family, respectively, and have been located at the sites of inflammatory conditions. We have observed in OX40L-deficient mice (OX40L(-/-)) an impaired APC capacity and in our recently constructed transgenic mice expressing OX40L (OX40L-Tg), a markedly enhanced T cell response to protein Ags. Using these mice, we demonstrate here the critical involvement of the OX40L-OX40… CONTINUE READING

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