Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain.

@article{Lange1994CriticalFO,
  title={Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain.},
  author={Elizabeth C. M. de Lange and Meindert Danhof and Albertus G de Boer and D. D. Breimer},
  journal={Brain research},
  year={1994},
  volume={666 1},
  pages={1-8}
}
The purpose of this investigation was to determine the effect of experimental conditions on the concentrations of atenolol and acetaminophen in brain microdialysate, and to investigate the feasibility of performing repeated experiments within individual rats. Following intravenous bolus administration, reproducible concentration-time profiles were obtained in plasma and in brain dialysate. Based on corrections for in vitro recoveries of the intracerebral probe, the estimated ratio of the AUC in… CONTINUE READING

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