Critical factors influencing prion inactivation by sodium hydroxide

  title={Critical factors influencing prion inactivation by sodium hydroxide},
  author={P. A. Bauman and L. Lawrence and L. Biesert and H. Dichtelm{\"u}ller and F. Fabbrizzi and R. Gajardo and A. Groener and J. Jorquera and C. Kempf and T. Kreil and I. von Hoegen and D. Pifat and S. Petteway and K. Cai},
  journal={Vox Sanguinis},
  • P. A. Bauman, L. Lawrence, +11 authors K. Cai
  • Published 2006
  • Medicine
  • Vox Sanguinis
  • Background and Objectives  Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases caused by aberrantly folded cellular proteins (PrPSc; prions) that are generally resistant to conventional pathogen‐inactivation techniques. To ensure effective decontamination and inactivation of prions that could be present in source material, we investigated critical factors that influence prion inactivation by NaOH. 
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