Critical factors influencing prion inactivation by sodium hydroxide

@article{Bauman2006CriticalFI,
  title={Critical factors influencing prion inactivation by sodium hydroxide},
  author={P. A. Bauman and L. Lawrence and L. Biesert and H. Dichtelm{\"u}ller and F. Fabbrizzi and R. Gajardo and A. Groener and J. Jorquera and C. Kempf and T. Kreil and I. von Hoegen and D. Pifat and S. Petteway and K. Cai},
  journal={Vox Sanguinis},
  year={2006},
  volume={91}
}
  • P. A. Bauman, L. Lawrence, +11 authors K. Cai
  • Published 2006
  • Medicine
  • Vox Sanguinis
  • Background and Objectives  Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases caused by aberrantly folded cellular proteins (PrPSc; prions) that are generally resistant to conventional pathogen‐inactivation techniques. To ensure effective decontamination and inactivation of prions that could be present in source material, we investigated critical factors that influence prion inactivation by NaOH. 
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    References

    SHOWING 1-10 OF 35 REFERENCES
    Inactivation of transmissible degenerative encephalopathy agents: A review.
    • D. Taylor
    • Biology, Medicine
    • Veterinary journal
    • 2000
    • 276
    Sodium hydroxide renders the prion protein PrPSc sensitive to proteinase K.
    • 36
    The same prion strain causes vCJD and BSE
    • 1,363
    • PDF
    Diagnosing prion diseases: needs, challenges and hopes
    • C. Soto
    • Medicine, Biology
    • Nature Reviews Microbiology
    • 2004
    • 90
    Immunodiagnosis of prion disease.
    • 51
    The public health impact of prion diseases.
    • 103
    The most infectious prion protein particles
    • 823
    • PDF
    Novel proteinaceous infectious particles cause scrapie.
    • 4,319
    • PDF