Critical evaluation of observed adverse effects of endocrine active substances on reproduction and development, the immune system, and the nervous system

@article{OConnor2003CriticalEO,
  title={Critical evaluation of observed adverse effects of endocrine active substances on reproduction and development, the immune system, and the nervous system},
  author={John C O'Connor and Robert E. Chapin},
  journal={Pure and Applied Chemistry},
  year={2003},
  volume={75},
  pages={2099 - 2123}
}
The last 40 years have seen many reports that man-made chemicals and environmental pollutants cause adverse effects in humans and wildlife; however, actually linking an exposure with a mechanism and an effect has yet to be done for endocrine disruption. Certainly, studies in experimental animals have shown that sufficient doses of select compounds can disrupt the endocrine system and produce the attendant adverse outcomes. The purpose of this contribution is to evaluate some of the recent… 

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