Critical elements of oligosaccharide acceptor substrates for the Pasteurella multocida hyaluronan synthase.

@article{Williams2006CriticalEO,
  title={Critical elements of oligosaccharide acceptor substrates for the Pasteurella multocida hyaluronan synthase.},
  author={Kellie J Williams and Koen M. Halkes and Johannis P. Kamerling and Paul L Deangelis},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 9},
  pages={5391-7}
}
Three-dimensional structures are not available for polysaccharide synthases and only minimal information on the molecular basis for catalysis is known. The Pasteurella multocida hyaluronan synthase (PmHAS) catalyzes the polymerization of the alternating beta1,3-N-acetylglucosamine-beta1,4-glucuronic acid sugar chain by the sequential addition of single monosaccharides to the non-reducing terminus. Therefore, PmHAS possesses both GlcNAc-transferase and glucuronic acid (GlcUA)-transferase… CONTINUE READING