Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity.

@article{Sledge2011CriticalDO,
  title={Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity.},
  author={Damiyon Sledge and James H. Yen and Terrell Roderick Morton and Laura Victoria Dishaw and Alessandro Petro and Susan Donerly and Elwood Linney and Edward D. Levin},
  journal={Neurotoxicology and teratology},
  year={2011},
  volume={33 6},
  pages={
          742-51
        }
}
Developmental exposure of rats to the pesticide chlorpyrifos (CPF) causes persistent neurobehavioral impairment. In a parallel series of studies with zebrafish, we have also found persisting behavioral dysfunction after developmental CPF exposure. We have developed a battery of measures of zebrafish behavior, which are reliable and sensitive to toxicant-induced damage. This study determined the critical duration of developmental CPF exposure for causing persisting neurobehavioral effects. Tests… CONTINUE READING
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