Critical dependence of respiratory rhythmicity on metabolic CO2 load.

@article{Phillipson1981CriticalDO,
  title={Critical dependence of respiratory rhythmicity on metabolic CO2 load.},
  author={Eliot A Phillipson and James Duffin and Joel David Cooper},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  year={1981},
  volume={50 1},
  pages={45-54}
}
We examined the dependence of respiratory rhythm generation on the rate of CO2 production (VCO2) in six awake sheep using a venous-to-venous extracorporeal perfusion circuit that included two carbon dioxide membrane lungs (CDML) designed to facilitate the removal of CO2 from blood. As progressively greater proportions of the resting VCO2, of the sheep were removed from the venous blood by the CDML, there were proportional reductions in pulmonary CO2 excretion and in minute volume of ventilation… CONTINUE READING

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