Critical dependence of respiratory rhythmicity on metabolic CO2 load.

  title={Critical dependence of respiratory rhythmicity on metabolic CO2 load.},
  author={Eliot A Phillipson and James Duffin and Joel David Cooper},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  volume={50 1},
We examined the dependence of respiratory rhythm generation on the rate of CO2 production (VCO2) in six awake sheep using a venous-to-venous extracorporeal perfusion circuit that included two carbon dioxide membrane lungs (CDML) designed to facilitate the removal of CO2 from blood. As progressively greater proportions of the resting VCO2, of the sheep were removed from the venous blood by the CDML, there were proportional reductions in pulmonary CO2 excretion and in minute volume of ventilation… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 41 extracted citations

Breathing without CO(2) chemosensitivity in conditional Phox2b mutants.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2011
View 4 Excerpts
Highly Influenced

How important is the CO2 chemoreflex for the control of breathing? Environmental and evolutionary considerations.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology • 2018
View 2 Excerpts

Similar Papers

Loading similar papers…