Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation.

@article{Shindo2013CriticalCO,
  title={Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation.},
  author={Ryodai Shindo and Hidenao Kakehashi and Ko Okumura and Yoshito Kumagai and Hiroyasu Nakano},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={436 2},
  pages={212-6}
}
While apoptosis has been considered to be identical to programmed cell death, necroptosis, which is morphologically related to necrosis, has emerged as a novel type of programmed cell death. Necroptosis depends on two structurally related kinases, receptor-interacting serine-threonine kinase (RIPK)1 and RIPK3. RIPK1 is activated through oligomerization of upstream adaptor molecules such as Fas-associated protein with death domain (FADD) and TNF receptor-associated death domain (TRADD) that are… CONTINUE READING

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