Critical contribution of nonlinear chromatography to the understanding of retention mechanism in reversed-phase liquid chromatography.

@article{Gritti2005CriticalCO,
  title={Critical contribution of nonlinear chromatography to the understanding of retention mechanism in reversed-phase liquid chromatography.},
  author={Fabrice Gritti and Georges Guiochon},
  journal={Journal of chromatography. A},
  year={2005},
  volume={1099 1-2},
  pages={
          1-42
        }
}
The retention of most compounds in RPLC proceeds through a combination of several independent mechanisms. We review a series of recent studies made on the behavior of several commercial C18-bonded stationary phases and of the complex, mixed retention mechanisms that were observed in RPLC. These studies are essentially based on the acquisition of adsorption isotherm data, on the modeling, and on the interpretation of these data. Because linear chromatography deals only with the initial slope of… CONTINUE READING

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