Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide.

@article{Hayakawa2001CriticalCO,
  title={Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide.},
  author={Yumiko Hayakawa and Kazuyoshi Takeda and H. Yagita and Shigeru Kakuta and Yoichiro Iwakura and Luc Van Kaer and Ikuo Saiki and Ko Okumura},
  journal={European journal of immunology},
  year={2001},
  volume={31 6},
  pages={1720-7}
}
The glycolipid alpha -galactosylceramide (alpha -GalCer), which is presented by CD1d and specifically activates Valpha 14 NKT cells, exerts a potent anti-metastatic effect when administered in vivo. In this study, we demonstrated that alpha -GalCer administration led to rapid elimination of NKT cells by apoptosis in the liver and spleen, after they produced IFN-gamma and IL-4. In contrast, a more prolonged secretion of IFN-gamma was observed by liver and splenic NK cells after alpha -GalCer… CONTINUE READING

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