Critical concepts in adaptive clinical trials

@inproceedings{Park2018CriticalCI,
  title={Critical concepts in adaptive clinical trials},
  author={Jay J H Park and Kristian Thorlund and Edward Mills},
  booktitle={Clinical epidemiology},
  year={2018}
}
Adaptive clinical trials are an innovative trial design aimed at reducing resources, decreasing time to completion and number of patients exposed to inferior interventions, and improving the likelihood of detecting treatment effects. The last decade has seen an increasing use of adaptive designs, particularly in drug development. They frequently differ importantly from conventional clinical trials as they allow modifications to key trial design components during the trial, as data is being… CONTINUE READING

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