Critical concepts in adaptive clinical trials

  title={Critical concepts in adaptive clinical trials},
  author={Jay J H Park and Kristian Thorlund and Edward Mills},
  booktitle={Clinical epidemiology},
Adaptive clinical trials are an innovative trial design aimed at reducing resources, decreasing time to completion and number of patients exposed to inferior interventions, and improving the likelihood of detecting treatment effects. The last decade has seen an increasing use of adaptive designs, particularly in drug development. They frequently differ importantly from conventional clinical trials as they allow modifications to key trial design components during the trial, as data is being… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 25 references

: a mixed methods analysis from the Adaptive Designs Accelerating Promising Trials into Treatments ( ADAPT - IT ) project

  • RH Bartlett, DW Roloff, RG Cornell, AF Andrews, PW Dillon
  • 2016

Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial

  • DF Hanley, RE Thompson, J Muschelli
  • Lancet Neurol
  • 2016

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