Critical aspects of the Bayesian approach to phase I cancer trials.

@article{Neuenschwander2008CriticalAO,
  title={Critical aspects of the Bayesian approach to phase I cancer trials.},
  author={Beat Neuenschwander and Michael Branson and Thomas Gsponer},
  journal={Statistics in medicine},
  year={2008},
  volume={27 13},
  pages={2420-39}
}
The Bayesian approach to finding the maximum-tolerated dose in phase I cancer trials is discussed. The suggested approach relies on a realistic dose-toxicity model, allows one to include prior information, and supports clinical decision making by presenting within-trial information in a transparent way. The modeling and decision-making components are flexible enough to be extendable to more complex settings. Critical aspects are emphasized and a comparison with the continual reassessment method… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
61 Citations
39 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 61 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

A method for obtaining and analyzing sensitivity data

  • W Dixon, A. Mood
  • Journal of the American Statistical Association
  • 1948
Highly Influential
7 Excerpts

A Bayesian approach to phase I cancer trials

  • B Neuenschwander, T Gsponer, M. Branson
  • Technical Report 2006-05-11,
  • 2006
1 Excerpt

Similar Papers

Loading similar papers…