Corpus ID: 45958877

Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of diclectin (doxylamine-B6).

@article{Bishai2000CriticalAO,
  title={Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of diclectin (doxylamine-B6).},
  author={Raafat Bishai and Paolo Mazzotta and G Atanackovic and Zina Levichek and Meena Pole and Laura A. Magee and Gideon Koren},
  journal={The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique},
  year={2000},
  volume={7 3},
  pages={
          138-43
        }
}
  • R. Bishai, P. Mazzotta, +4 authors G. Koren
  • Published 2000
  • Medicine
  • The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique
Nausea and vomiting of pregnancy is the most common condition in pregnancy and affects up to 80% of all pregnant women. There are a large number of pharmacological agents that are effective for the treatment of nausea and vomiting associated with conditions such as motion sickness and gastrointestinal conditions; however, their use in pregnancy is limited by the lack of sufficient data on their potential teratogenic effects. The efficacy of the delayed-release combination of doxylamine and… Expand
The safety of drugs for the treatment of nausea and vomiting of pregnancy
TLDR
Different classes of antiemetics used to treat NVP are reviewed and it is discussed that some have better safety profiles than others, but most appear to be safe to use in pregnancy. Expand
Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing.
TLDR
Women suffering from NVP are often given subtherapeutic doses of Diclectin, and should receive a dosage according to their body weight and severity of their symptoms, according to the validated PUQE scoring system. Expand
Optimal management of nausea and vomiting of pregnancy
TLDR
Optimal medical management of symptoms will ensure the mental and physical wellbeing of expecting mothers and their developing babies during this often stressful and difficult time period. Expand
The Delayed-Release Combination of Doxylamine and Pyridoxine (Diclegis®/Diclectin®) for the Treatment of Nausea and Vomiting of Pregnancy
TLDR
The scientific evidence on the effectiveness and fetal safety of Diclegis/Diclectin® for the treatment of NVP is presented to justify its use as first-line treatment for NVP. Expand
DICLECTIN THERAPY FOR NAUSEA AND VOMITING OF .
TLDR
Women suffering from NVP are often given subtherapeutic doses of Diclectin, and should receive a dosage according to their body weight and severity of their symptoms. Expand
The Safety of Higher Than Standard Dose of Doxylamine‐Pyridoxine (Diclectin®) for Nausea and Vomiting of Pregnancy
TLDR
It was concluded that the higher than standard dose of Diclectin®, when calculated per kg of body weight, does not affect either the incidence of maternal adverse effects or pregnancy outcome. Expand
The Management of Nausea and Vomiting of Pregnancy.
TLDR
Nausea and vomiting of pregnancy has a profound effect on women's health and quality of life during pregnancy as well as a financial impact on the health care system, and its early recognition and management is recommended. Expand
Management of nausea and vomiting in pregnancy
  • M. Arsenault, C. Lane, +6 authors A. Wilson
  • Medicine
  • Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
  • 2002
TLDR
NVP has a profound effect on women's health and quality of life during pregnancy, as well as a financial impact on the health care system, and its early recognition and management are recommended. Expand
Treating morning sickness in the United States--changes in prescribing are needed.
  • G. Koren
  • Medicine
  • American journal of obstetrics and gynecology
  • 2014
TLDR
Now that a safe and effective drug is available in the United States, there is no reason for women to be exposed to a drug of unproven maternal and fetal safety. Expand
8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information
TLDR
The available information about this “8-way Bendectin” trial indicates it should not be used to support the efficacy of doxylamine, pyridoxine or dicyclomine for the treatment of nausea and vomiting during pregnancy because of a high risk of bias. Expand
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TLDR
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TLDR
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TLDR
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