Critical analysis of reference studies on the toxicokinetics of aluminum-based adjuvants.

@article{Masson2017CriticalAO,
  title={Critical analysis of reference studies on the toxicokinetics of aluminum-based adjuvants.},
  author={Jean-Daniel Masson and Guillemette Cr{\'e}peaux and François-j{\'e}r{\^o}me Authier and Christopher Exley and Romain Kroum Gherardi},
  journal={Journal of inorganic biochemistry},
  year={2017},
  volume={181},
  pages={
          87-95
        }
}
We reviewed the three toxicokinetic reference studies commonly used to suggest that aluminum (Al)-based adjuvants are innocuous. A single experimental study was carried out using isotopic 26Al (Flarend et al., Vaccine, 1997). This study used aluminum salts resembling those used in vaccines but ignored adjuvant uptake by cells that was not fully documented at the time. It was conducted over a short period of time (28days) and used only two rabbits per adjuvant. At the endpoint, Al elimination in… CONTINUE READING
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