Critical analysis of endocrine disruptive activity of triclosan and its relevance to human exposure through the use of personal care products

@article{Witorsch2014CriticalAO,
  title={Critical analysis of endocrine disruptive activity of triclosan and its relevance to human exposure through the use of personal care products},
  author={R. Witorsch},
  journal={Critical Reviews in Toxicology},
  year={2014},
  volume={44},
  pages={535 - 555}
}
  • R. Witorsch
  • Published 2014
  • Biology, Medicine
  • Critical Reviews in Toxicology
Abstract This review examines the mammalian and human literature pertaining to the potential endocrine disruptive effects of triclosan (TCS). Dietary exposure to TCS consistently produces a dose-dependent decrease in serum thyroxine (T4) in rats without any consistent change in TSH or triiodothyronine (T3). Human studies reveal no evidence that the TCS exposure through personal care product use affects the thyroid system. TCS binds to both androgen and estrogen receptors in vitro with low… Expand
In vitro and in vivo estrogenic activity of triclosan
TLDR
In vitro and gene-profiling results suggested that TCS exhibited estrogenic activity, which is known to induce endocrine disruption in women and to be consistent with previous reports on triclosan. Expand
Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation study.
TLDR
Exposure to TCS at low doses did not act as an endocrine disruptor in the female rat reproductive system, and no impairment was observed in the uterotrophic assay and other important reproductive endpoints. Expand
Evaluation of triclosan in the Hershberger and H295R steroidogenesis assays.
TLDR
TCS had no effect on androgen synthesis or activity in the models used, but did enhance estrogen production and suppress serum T4. Expand
Is Triclosan a neurotoxic agent?
TLDR
The aim of this review was to summarize the current findings on the neurotoxic effects of TCS and broaden the discussion to other effects of CCS, which might plausibly be related to neuronal functions, to help clarify the mechanisms underlying TCS-mediated toxicity. Expand
Impact of Triclosan on Female Reproduction through Reducing Thyroid Hormones to Suppress Hypothalamic Kisspeptin Neurons in Mice
TLDR
Exposure of adult female mice to TCS (≥10 mg/kg) reduces thyroid hormones causing hyperprolactinemia that then suppresses hypothalamic kisspeptin expression, leading to deficits in reproductive endocrine and function. Expand
Triclosan in over the counter medicines of South China
TLDR
Compared to other potential sources, human exposure to TCS from OTCs was limited in China—much less than TCS exposure through personal care products or indoor dust. Expand
Temporal variability and sources of triclosan exposure in pregnancy.
TLDR
The first data on temporal variability of urinary TCS concentrations and predictors of exposure in Canadian pregnant women is provided and can inform exposure assessments in pregnant women and justify collection of single spot urine samples in epidemiologic studies, especially for women with higher exposures. Expand
Triclosan exposure, transformation, and human health effects
TLDR
The aim of this review was to describe TCS exposure routes and levels as well as metabolism and transformation processes, and the burgeoning literature on human health effects associated with T CS exposure, such as reproductive problems, was summarized. Expand
Investigations of immunotoxicity and allergic potential induced by topical application of triclosan in mice
TLDR
It is demonstrated that dermal exposure to triclosan induces stimulation of the immune system in a murine model and raise concerns about potential human exposure. Expand
Research Progress on Toxic Effects and Water Quality Criteria of Triclosan
TLDR
A literature review of recent studies on the toxic effects of TCS from different aspects at the molecular, cell, tissue, organ, and individual level finds that TCS exerts significant endocrine-disrupting effects on organisms, interfering the normal physiological functions of the reproductive, thyroid, and nervous systems. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 99 REFERENCES
Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine.
TLDR
It is demonstrated that triclosan disrupts thyroid hormone homeostasis in rats by altering circulating concentrations of thyroxine. Expand
Triclosan exposure modulates estrogen-dependent responses in the female wistar rat.
TLDR
Triclosan affected estrogen-mediated responses in the pubertal and weanling female rat and also suppressed thyroid hormone in both studies, similar to other studies in the male and female rat. Expand
Triclosan: A critical review of the experimental data and development of margins of safety for consumer products
TLDR
Exposure to triclosan in consumer products is not expected to cause adverse health effects in children or adults who use these products as intended and a Benchmark Dose (BMDL10) was developed based on kidney toxicity in the hamster. Expand
The effect of triclosan on the uterotrophic response to extended doses of ethinyl estradiol in the weanling rat.
TLDR
The TCS-induced potentiation was independent of ER activation, as no effects were observed in the ER TA assay, and TCS increased the EE-induced stimulation of epithelial cell height following cotreatment. Expand
Potential estrogenic activity of triclosan in the uterus of immature rats and rat pituitary GH3 cells.
TLDR
Results indicate that TCS has an estrogen-like property, which may be mediated through an ER-involved signaling pathway in both in vivo and in vitro models. Expand
In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens
TLDR
Carbanilides, including TCC, enhanced hormone-dependent induction of ER- and AR-dependent gene expression but had little agonist activity, suggesting a new mechanism of action of endocrine-disrupting compounds. Expand
Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones.
Triclosan is an antibacterial compound commonly used in cosmetics and personal care products for everyday use. As previously shown, triclosan is found in the plasma, urine and milk from large partsExpand
Personal care products and endocrine disruption: A critical review of the literature
TLDR
Although select constituents exhibit interactions with the endocrine system in the laboratory, the evidence linking personal care products to endocrine disruptive effects in humans is for the most part lacking. Expand
Comment on "Effects of triclocarban, triclosan, and methyl triclosan on thyroid hormone action and stress in frog and mammalian culture systems".
TLDR
The present study uses the cultured frog tadpole tail fin biopsy (C-fin) assay and the TH-responsive rat pituitary GH3 cell line to assess the effects of these three chemicals on TH signaling and cellular stress within 48 h. Expand
Estrogenic and androgenic activity of PCBs, their chlorinated metabolites and other endocrine disruptors estimated with two in vitro yeast assays.
TLDR
Comparison of the estrogen screening assay based on beta-galactosidase expression and a bioluminescent estrogen screen revealed differences in the sensitivity and specificity of the two tests, indicating possible transitions of the hormonal activity of PCBs during bacterial degradation. Expand
...
1
2
3
4
5
...