Critical ages in the life course of the adult brain: nonlinear subcortical aging.

  title={Critical ages in the life course of the adult brain: nonlinear subcortical aging.},
  author={Anders M. Fjell and Lars T. Westlye and H{\aa}kon Grydeland and Inge K. Amlien and Thomas Espeseth and Ivar Reinvang and Naftali Raz and Dominic Holland and Anders M. Dale and Kristine B. Walhovd},
  journal={Neurobiology of aging},
  volume={34 10},
Age-related changes in brain structure result from a complex interplay among various neurobiological processes, which may contribute to more complex trajectories than what can be described by simple linear or quadratic models. We used a nonparametric smoothing spline approach to delineate cross-sectionally estimated age trajectories of the volume of 17 neuroanatomic structures in 1100 healthy adults (18-94 years). Accelerated estimated decline in advanced age characterized some structures, for… CONTINUE READING
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