Critical Steps toward a tissue-engineered cartilage implant using embryonic stem cells.

@article{Jukes2008CriticalST,
  title={Critical Steps toward a tissue-engineered cartilage implant using embryonic stem cells.},
  author={Jojanneke M Jukes and Lorenzo Moroni and Clemens A van Blitterswijk and Jan-Paul de Boer},
  journal={Tissue engineering. Part A},
  year={2008},
  volume={14 1},
  pages={135-47}
}
Embryonic stem (ES) cells are a potential source for cartilage tissue engineering because they provide an unlimited supply of cells that can be differentiated into chondrocytes. So far, chondrogenic differentiation of both mouse and human ES cells has only been demonstrated in two-dimensional cultures, in pellet cultures, in a hydrogel, or on thin biomaterials. The next challenge will be to form cartilage on a load-bearing, clinically relevant-sized scaffold in vitro and in vivo, to regenerate… CONTINUE READING

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