Critical Roles of the p110β Subtype of Phosphoinositide 3-Kinase in Lipopolysaccharide-Induced Akt Activation and Negative Regulation of Nitrite Production in RAW 264.7 Cells

@article{Tsukamoto2008CriticalRO,
  title={Critical Roles of the p110β Subtype of Phosphoinositide 3-Kinase in Lipopolysaccharide-Induced Akt Activation and Negative Regulation of Nitrite Production in RAW 264.7 Cells},
  author={Ken Tsukamoto and K. Hazeki and M. Hoshi and K. Nigorikawa and N. Inoue and T. Sasaki and O. Hazeki},
  journal={The Journal of Immunology},
  year={2008},
  volume={180},
  pages={2054 - 2061}
}
  • Ken Tsukamoto, K. Hazeki, +4 authors O. Hazeki
  • Published 2008
  • Biology, Medicine
  • The Journal of Immunology
    • It has been suggested that PI3K participates in TLR signaling. However, identifying specific roles for individual PI3K subtypes in signaling has remained elusive. In macrophages from the p110γ−/− mouse, LPS-induced phosphorylation of Akt occurred normally despite the fact that the action of anaphylatoxin C5a was impaired markedly. In RAW 264.7 cells expressing short hairpin RNA that targets p110β, LPS-induced phosphorylation of Akt was significantly attenuated. In contrast, the LPS action was… CONTINUE READING
    View on Publisher
    jimmunol.org
    58 Citations
    Highly Influential Citations
    1
    Background Citations
    22
    Methods Citations
    2
    Results Citations
    3
    58 Citations
    Citation Type

    Citation Type

    Veratric acid inhibits iNOS expression through the regulation of PI3K activation and histone acetylation in LPS-stimulated RAW264.7 cells.
    • 9
    • PDF
    Cross Talk between the Akt and p38α Pathways in Macrophages Downstream of Toll-Like Receptor Signaling
    • 62
    • PDF
    The p110α and p110β Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells
    • 4
    • PDF
    PI3K p110β Positively Regulates Lipopolysaccharide-Induced IL-12 Production in Human Macrophages and Dendritic Cells and JNK1 Plays a Novel Role1
    • 48
    • PDF
    Role of protein kinase C and phosphoinositide 3‐kinase‐Akt in substance P‐induced proinflammatory pathways in mouse macrophages
    • 48
    Negative regulation of class IA phosphoinositide 3-kinase by protein kinase Cdelta Limits Fcgamma receptor-mediated phagocytosis in macrophages.
    • 8
    • PDF
    Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model
    • 2
    Mer receptor tyrosine kinase negatively regulates lipoteichoic acid-induced inflammatory response via PI3K/Akt and SOCS3.
    • 21
    Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-α in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways
    • 53
    JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells.
    • 10

    References

    SHOWING 1-10 OF 54 REFERENCES
    Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages.
    • 132
    Role of phosphoinositide 3-kinase in innate immunity.
    • 200
    • PDF
    Involvement of Phosphoinositide 3-Kinases in Neutrophil Activation and the Development of Acute Lung Injury1
    • 190
    • Highly Influential
    • PDF
    Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
    • 431
    • PDF
    Class I and III Phosphatidylinositol 3′-Kinase Play Distinct Roles in TLR Signaling Pathway1
    • 75
    • Highly Influential
    • PDF
    Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt.
    • 39
    • PDF
    Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
    • 1,083
    Role of MyD88 in Phosphatidylinositol 3-Kinase Activation by Flagellin/Toll-like Receptor 5 Engagement in Colonic Epithelial Cells*
    • 98
    • PDF
    Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction
    • 757
    Activation of phosphatidylinositol 3-kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role of the G-protein-coupled signals for the lectin-induced respiratory burst in human monocytic THP-1 cells.
    • 33
    • PDF