Critical Roles of the p110β Subtype of Phosphoinositide 3-Kinase in Lipopolysaccharide-Induced Akt Activation and Negative Regulation of Nitrite Production in RAW 264.7 Cells

@article{Tsukamoto2008CriticalRO,
  title={Critical Roles of the p110β Subtype of Phosphoinositide 3-Kinase in Lipopolysaccharide-Induced Akt Activation and Negative Regulation of Nitrite Production in RAW 264.7 Cells},
  author={Ken Tsukamoto and K. Hazeki and M. Hoshi and K. Nigorikawa and N. Inoue and T. Sasaki and O. Hazeki},
  journal={The Journal of Immunology},
  year={2008},
  volume={180},
  pages={2054 - 2061}
}
  • Ken Tsukamoto, K. Hazeki, +4 authors O. Hazeki
  • Published 2008
  • Biology, Medicine
  • The Journal of Immunology
  • It has been suggested that PI3K participates in TLR signaling. However, identifying specific roles for individual PI3K subtypes in signaling has remained elusive. In macrophages from the p110γ−/− mouse, LPS-induced phosphorylation of Akt occurred normally despite the fact that the action of anaphylatoxin C5a was impaired markedly. In RAW 264.7 cells expressing short hairpin RNA that targets p110β, LPS-induced phosphorylation of Akt was significantly attenuated. In contrast, the LPS action was… CONTINUE READING
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