Critical Roles of Glutaredoxin in Brain Cells-Implications for Parkinson's Disease.

  title={Critical Roles of Glutaredoxin in Brain Cells-Implications for Parkinson's Disease.},
  author={Olga Gorelenkova Miller and J. Mieyal},
  journal={Antioxidants \& redox signaling},
  volume={30 10},
SIGNIFICANCE Glutaredoxin (Grx)1, an evolutionarily conserved and ubiquitous enzyme, regulates redox signal transduction and protein redox homeostasis by catalyzing reversible S-glutathionylation. Grx1 plays different roles in different cell types. In Parkinson's disease (PD), Grx1 regulates apoptosis signaling in dopaminergic neurons, so that loss of Grx1 leads to increased cell death; in microglial cells, Grx1 regulates proinflammatory signaling, so that upregulation of Grx1 promotes cytokine… Expand
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