Critical Role of the Virus-Encoded MicroRNA-155 Ortholog in the Induction of Marek's Disease Lymphomas

@inproceedings{Zhao2011CriticalRO,
  title={Critical Role of the Virus-Encoded MicroRNA-155 Ortholog in the Induction of Marek's Disease Lymphomas},
  author={Yuguang Zhao and Hongtao Xu and Yongxiu Yao and Lorraine P. Smith and Lydia B. Kgosana and James Green and Lawrence J. Petherbridge and Susan J. Baigent and Venugopal Nair},
  booktitle={PLoS pathogens},
  year={2011}
}
Notwithstanding the well-characterised roles of a number of oncogenes in neoplastic transformation, microRNAs (miRNAs) are increasingly implicated in several human cancers. Discovery of miRNAs in several oncogenic herpesviruses such as KSHV has further highlighted the potential of virus-encoded miRNAs to contribute to their oncogenic capabilities. Nevertheless, despite the identification of several possible cancer-related genes as their targets, the direct in vivo role of virus-encoded miRNAs… CONTINUE READING

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