Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function.

@article{Lin2012CriticalRO,
  title={Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function.},
  author={Jian-xin Lin and Peng P. Li and Delong Liu and Hyun Tak Jin and Jianping He and Mohammed Ata Ur Rasheed and Yrina Rochman and Lu Wang and Kairong Cui and Chengyu Liu and Brian Lee Kelsall and Rafi Ahmed and Warren J Leonard},
  journal={Immunity},
  year={2012},
  volume={36 4},
  pages={586-99}
}
Cytokine-activated STAT proteins dimerize and bind to high-affinity motifs, and N-terminal domain-mediated oligomerization of dimers allows tetramer formation and binding to low-affinity tandem motifs, but the functions of dimers versus tetramers are unknown. We generated Stat5a-Stat5b double knockin (DKI) N-domain mutant mice in which STAT5 proteins form dimers but not tetramers, identified cytokine-regulated genes whose expression required STAT5 tetramers, and defined dimer versus tetramer… CONTINUE READING
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