Critical Role of L-Selectin and Histamine H4 Receptor in Zymosan-Induced Neutrophil Recruitment from the Bone Marrow: Comparison with Carrageenan

@article{Takeshita2004CriticalRO,
  title={Critical Role of L-Selectin and Histamine H4 Receptor in Zymosan-Induced Neutrophil Recruitment from the Bone Marrow: Comparison with Carrageenan},
  author={Keisuke Takeshita and Kevin B. Bacon and Florian Gantner},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2004},
  volume={310},
  pages={272 - 280}
}
Zymosan and carrageenan represent two inflammatory stimuli leading to significant neutrophilia when injected into mice. Despite several similarities between the two proinflammatory agents, the mechanisms leading to neutrophil influx into the site of stimulus injection are unclear. As demonstrated by antibody (Ab) studies directed against adhesion molecules, L-selectin was pivotal for zymosan-induced but not carrageenan-induced pleurisy. Zymosan but not carrageenan injection into the pleural… 

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References

SHOWING 1-10 OF 40 REFERENCES

Critical Role of Histamine H4 Receptor in Leukotriene B4 Production and Mast Cell-Dependent Neutrophil Recruitment Induced by Zymosan in Vivo

TLDR
Reduced levels of the neutrophil chemattractant leukotriene B4 were observed upon pretreatment with thioperamide, providing a mechanistic explanation for the prevention of neutrophilia by H4 receptor antagonism.

In vivo characterization of zymosan-induced mouse peritoneal inflammation.

TLDR
It is suggested that both 5-LO and CO metabolites regulate neutrophil influx in this model, and marked eicosanoid biosynthesis and cellular influx in response to zymosan provides an attractive experimental paradigm to evaluate anti-inflammatory effects of inhibitors of arachidonate CO or 5- LO pathways.

Involvement of platelet-activating factor in zymosan-induced rat pleurisy

TLDR
The results suggest that in zymosan-induced rat pleurisy, histamine and/or serotonin are the main mediators of exudation at 0.5 hr and that PAF may be partly responsible for exUDation at0.5 hrs.

Effects of ketoprofen and indomethacin on leukocyte migration in two models of pleurisy induced by carrageenan or zymosan-activated serum in rats.

TLDR
It is demonstrated that ketoprofen is more active than indomethacin in reducing the in vivo leukocyte migration evoked by carrageenan or ZAS and suggested that the main effect of these two drugs is to reduce the increase in vascular permeability.

The effect of glucocorticoids on the expression of L-selectin on polymorphonuclear leukocyte.

TLDR
It is concluded that glucocorticoids decrease L-selectin expression on circulating PMN by downregulating L- selectin expression in the maturation pool of bone marrow and speculate that this is an important glucocortsicoid effect that influences the recruitment of PMN into inflammatory sites.

[Analysis of chemical mediators involved in acute inflammatory reaction with the rat pleurisy model].

  • S. Oh‐ishi
  • Biology, Medicine
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica
  • 1997
TLDR
Results suggest that chemokines, directly or indirectly, may partly cause neutrophil migration in the pleural exudates during carrageenin- and zymosan-induced pleurisy.

Pharmacological studies on zymosan inflammation in rats and mice. 2: Zymosan-induced pleurisy in rats.

Effect of selected antiinflammatory agents and other drugs on zymosan, arachidonic acid, PAF and carrageenan induced paw edema in the mouse

TLDR
The inhibitory activities of dual 5-lo/CO inhibitors and NSAIDs were not different in the zymosan, carrageenan and AA edema models in the mouse; however, some selectivity for 5-LO inhibitors was observed in the PAF model.

Captopril uncovers kinin-dependent release of arachidonic acid metabolites in carrageenin-induced rat pleurisy.

TLDR
The results indicate that captopril uncovers the effects of bradykinin on exudation and stimulation of arachidonate metabolite production; otherwise, the biological effect of kinin is too slight to produce a clear effect at the initial phase of the inflammation.