Critical Role for Ventral Tegmental Glutamate in Preference for a Cocaine-Conditioned Environment

  title={Critical Role for Ventral Tegmental Glutamate in Preference for a Cocaine-Conditioned Environment},
  author={Glenda C. Harris and Gary Aston-Jones},
Cocaine administration induces glutamatergic activation within the mesolimbic-accumbens system. This activation has been linked to the behavioral effects of cocaine and recently to the induction of long-term potentiation in dopamine neurons within the ventral tegmental area (VTA). We sought to determine if glutamate receptor activation is also crucial to the development of a conditioned place preference (CPP) to cocaine's rewarding effects. Two groups of rats were given intra-VTA injections of… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 85 extracted citations

Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure

Neuropsychopharmacology • 2016
View 9 Excerpts
Highly Influenced

Learning and memory in the aetiopathogenesis of addiction: future implications for therapy?

European Archives of Psychiatry and Clinical Neuroscience • 2009
View 7 Excerpts
Highly Influenced

Glutamatergic substrates of drug addiction and alcoholism.

Biochemical pharmacology • 2008
View 20 Excerpts
Highly Influenced

Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms

Neuropsychopharmacology • 2008
View 4 Excerpts
Highly Influenced

Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents cocaine sensitization and decreases cocaine preference.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 29 references

The Rat Brain in Stereotaxic Coordinates

Trends in Neurosciences • 1984
View 2 Excerpts
Highly Influenced

Single cocaine exposure in vivo induces long-term potentiation in dopamine

MA Ungless, JL Whistler, RC Malenka, A Bonci
neurons. Nature • 2001

Similar Papers

Loading similar papers…