Critical Role for Ventral Tegmental Glutamate in Preference for a Cocaine-Conditioned Environment

@article{Harris2003CriticalRF,
  title={Critical Role for Ventral Tegmental Glutamate in Preference for a Cocaine-Conditioned Environment},
  author={Glenda C. Harris and Gary Aston-Jones},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={73-76}
}
Cocaine administration induces glutamatergic activation within the mesolimbic-accumbens system. This activation has been linked to the behavioral effects of cocaine and recently to the induction of long-term potentiation in dopamine neurons within the ventral tegmental area (VTA). We sought to determine if glutamate receptor activation is also crucial to the development of a conditioned place preference (CPP) to cocaine's rewarding effects. Two groups of rats were given intra-VTA injections of… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 29 references

The Rat Brain in Stereotaxic Coordinates

Trends in Neurosciences • 1984
View 2 Excerpts
Highly Influenced

Single cocaine exposure in vivo induces long-term potentiation in dopamine

MA Ungless, JL Whistler, RC Malenka, A Bonci
neurons. Nature • 2001

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