Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA*>

@article{Kanneganti2006CriticalRF,
  title={Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA*>},
  author={Thirumala‐Devi Kanneganti and Mathilde Body-Malapel and Amal O. Amer and Jong-Hwan Park and Joel R. Whitfield and Luigi Franchi and Zenobia F. Taraporewala and David Miller and John Thomas Patton and Naohiro Inohara and Gabriel N{\'u}{\~n}ez},
  journal={Journal of Biological Chemistry},
  year={2006},
  volume={281},
  pages={36560 - 36568}
}
Viral infection induces the production of interleukin (IL)-1β and IL-18 in macrophages through the activation of caspase-1, but the mechanism by which host cells sense viruses to induce caspase-1 activation is unknown. In this report, we have identified a signaling pathway leading to caspase-1 activation that is induced by double-stranded RNA (dsRNA) and viral infection that is mediated by Cryopyrin/Nalp3. Stimulation of macrophages with dsRNA, viral RNA, or its analog poly(I:C) induced the… 
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.
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Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux
TLDR
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Bacterial RNA Mediates Activation of Caspase-1 and IL-1β Release Independently of TLRs 3, 7, 9 and TRIF but Is Dependent on UNC93B
TLDR
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Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection
TLDR
A role for NOD2-RIPK2 signaling is demonstrated in protection against virally triggered immunopathology by negatively regulating activation of the NLRP3 inflammasome and production of IL-18 via ULK1-dependent mitophagy.
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References

SHOWING 1-10 OF 57 REFERENCES
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.
TLDR
It is shown that ASC- and NALP3-deficient mice also demonstrate an impaired contact hypersensitivity response to the hapten trinitrophenylchloride, suggesting that NALp3 plays a specific role in the caspase-1 activation pathway.
Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes1
TLDR
Analysis of Listeria mutants revealed that cytosolic invasion was required for ASC-dependent IL-1β secretion, consistent with a critical role for cytosol signaling in the activation of caspase-1.
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
TLDR
A critical role for cryopyrin in host defence through bacterial RNA-mediated activation of caspase-1 is revealed and insights regarding the pathogenesis of autoinflammatory syndromes are provided.
Cryopyrin activates the inflammasome in response to toxins and ATP
TLDR
It is shown that cryopyrin-deficient macrophages cannot activate caspase-1 in response to Toll-like receptor agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.
A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection.
TLDR
The identification and characterization of a poxvirus-encoded PYD-containing protein that interacts with the ASC-1 component of the inflammasome and inhibits caspase-1 activation and the processing of IL-1beta and IL-18 induced by diverse stimuli is reported.
Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome
TLDR
It is shown that bacterial peptidoglycans (PGN), but surprisingly not LPS, induce NALP3-mediated activation of caspase-1 and maturation of proIL-1beta, which may be the basis of the potent adjuvant activity of MDP.
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
TLDR
It is shown that proinflammatory caspase activation and proIL-1beta processing is lost upon prior immunodepletion of Pycard, and the inflammasome constitutes an important arm of the innate immunity.
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts
TLDR
It is concluded that TBK1 is essential for IRF3-dependent antiviral gene expression after infection with either Sendai or Newcastle disease viruses or after engagement of the Toll-like receptors 3 and 4 by double-stranded RNA and lipopolysaccharide.
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
TLDR
It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs).
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
Intracellular double-stranded RNA (dsRNA) is a chief sign of replication for many viruses. Host mechanisms detect the dsRNA and initiate antiviral responses. In this report, we identify retinoic acid
...
1
2
3
4
5
...