Critical Review: What Dose of Rifabutin Is Recommended With Antiretroviral Therapy?

@article{Yapa2016CriticalRW,
  title={Critical Review: What Dose of Rifabutin Is Recommended With Antiretroviral Therapy?},
  author={H Manisha N Yapa and Marta Boffito and Anton Louis Pozniak},
  journal={Journal of acquired immune deficiency syndromes},
  year={2016},
  volume={72 2},
  pages={138-52}
}
Since the advent of combination antiretroviral therapy to successfully treat HIV infection, drug-drug interactions (DDIs) have become a significant problem as many antiretrovirals (ARVs) are metabolized in the liver. Antituberculous therapy traditionally includes rifamycins, particularly rifampicin. Rifabutin (RBT) has shown similar efficacy as rifampicin but induces CYP3A4 to a lesser degree and is less likely to have DDIs with ARVs. We identified 14 DDI pharmacokinetic studies on HIV… CONTINUE READING
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