Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-21

@inproceedings{Heckman2003CriticalEO,
  title={Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-21},
  author={Caroline A Heckman and Thai M. Cao and Lina Somsouk and Hong Duan and John W. Mehew and Chun-yi Zhang and Linda M. Boxer},
  year={2003}
}
Translocation of the bcl-2 gene to the immunoglobulin heavy chain gene is the most common alteration in follicular lymphoma. The result is the deregulated expression of bcl-2 and increased resistance to cell death. Regulation of the immunoglobulin heavy chain gene is controlled in part by four DNase I-hypersensitive regions located 3 of the gene. Here, we… CONTINUE READING