Critical Appraisal of Therapeutic Interventions in the Intensive Care Unit: Human Monoclonal Antibody Treatment in Sepsis

  title={Critical Appraisal of Therapeutic Interventions in the Intensive Care Unit: Human Monoclonal Antibody Treatment in Sepsis},
  author={Deborah J. Cook and Roman Z. Jaeschke and Gordon H. Guyatt},
  journal={Journal of Intensive Care Medicine},
  pages={275 - 282}
Using the medical literature to solve patient problems is challenging and rewarding. For intensive care physicians, this evidence-based medicine approach is more compelling when basic critical appraisal skills are developed. We highlight the important methodological points for interpreting the literature on treatment, using a cogent example from the critical care literature—monoclonal antibody therapy in sepsis. It is likely that as we move into the 1990s, growth in the number in the number of… 

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