Criteria for the selection of single nucleotide polymorphisms in pathway pharmacogenetics: TNF inhibitors as a case study.

@article{Kooloos2009CriteriaFT,
  title={Criteria for the selection of single nucleotide polymorphisms in pathway pharmacogenetics: TNF inhibitors as a case study.},
  author={Wouter M Kooloos and Judith A. M. Wessels and Tahar van der Straaten and Thomas W. J. Huizinga and Henk-Jan Guchelaar},
  journal={Drug discovery today},
  year={2009},
  volume={14 17-18},
  pages={837-44}
}
Pharmacogenetics aims to identify genetic variation to predict drug response or to establish an individual optimal dose. Classically, explorative pharmacogenetic studies are performed concerning a limited number of SNPs in genes encoding enzymes involved in the drug's metabolic route. Alternatively, potential markers across the genome are elucidated by the performance of the hypothesis-free genome-wide method. Besides their successful use, both methods provide substantial disadvantages. A… CONTINUE READING
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