Criteria for diagnosis of pure neural leprosy
@article{Jardim2003CriteriaFD, title={Criteria for diagnosis of pure neural leprosy}, author={M�rcia R. Jardim and S�rgio L. G. Antunes and Adalberto Rezende Santos and Osvaldo Jos{\'e} Moreira Nascimento and Jos{\'e} Augusto C. Nery and Anna Maria Sales and Ximena Illarramendi and N�dia Duppre and Leila Chimelli and Elizabeth Pereira Sampaio and Euzenir Nunes Sarno}, journal={Journal of Neurology}, year={2003}, volume={250}, pages={806-809} }
Abstract.The clinical diagnosis of pure neural leprosy (PNL)
remains a public health care problem mainly because skin
lesions—the cardinal features of leprosy—are always
absent.Moreover, the identification of the leprosy bacillus is
not easily achieved even when a nerve biopsy can be performed.
In an attempt to reach a reliable PNL diagnosis in patients
referred to our Leprosy Outpatient Clinic, this study employed a
variety of criteria. The nerve biopsies performed on the 67
individuals whose…
123 Citations
Revisiting primary neural leprosy: Clinical, serological, molecular, and neurophysiological aspects
- Medicine, BiologyPLoS neglected tropical diseases
- 2017
PNL is not a synonym of pure neural leprosy, as this condition may include a generalized immune response and also a skin involvement, documented by molecular findings.
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- Medicine, Biology
- 2015
The clinical and epidemiological findings plus with the electroneuromyography alteration were finally accepted as sufficient criteria to diagnose PNL.
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- MedicineJournal of the peripheral nervous system : JPNS
- 2020
A comprehensive electrophysiologic, ultrasonographic, and histological evaluation may be helpful in establishing a diagnosis of PNL with greater confidence, while ruling out other non‐leprosy diagnoses.
Leprosy and the peripheral nervous system: Basic and clinical aspects
- Medicine, BiologyMuscle & nerve
- 2004
Electrodiagnostic findings early in the disease reveal demyelinating features, such as slowing of conduction velocity and prolongation of latencies, but as the disease progresses secondary axonal damage commonly ensues, and electrodes are used to monitor for toxicity secondary to therapy, particularly thalidomide‐associated neuropathy.
Neural Leprosy: A case report
- Medicine
- 2016
Serological test of anti PGL-1 can be a marker and a useful tool as an additional test to confirm the diagnosis, especially for patients with nerve impairments, and both diagnosis and treatment require multidisciplinary approach.
Microscopic leprosy skin lesions in primary neuritic leprosy.
- Medicine, BiologyJournal of the American Academy of Dermatology
- 2005
Pure Neuritic Leprosy in India : an Appraisal 1
- Medicine
- 2011
PNL is a distinct subset of disease frequently seen in India and there is need to pay more attention to this form of leprosy and diagnose and treat patients earlier to prevent deformities and sequelae of nerve damage.
[Diagnosis and treatment of leprous neuropathy in practice].
- Medicine, BiologyRevue neurologique
- 2012
Role of PGL-I antibody detection in the diagnosis of pure neural leprosy.
- Medicine, BiologyLeprosy review
- 2005
Pure neural leprosy (PNL) is difficult to diagnose because skin lesions and acid-fast bacilli (AFB) in slit smears are absent. At present, the gold standard for PNL diagnosis is the histopathological…
Follow-up assessment of patients with Pure Neural Leprosy in a reference center in Rio de Janeiro—Brazil
- MedicinePLoS neglected tropical diseases
- 2022
unique characteristics of PNL in the spectrum of leprosy are highlighted in an attempt to facilitate the diagnosis and management of these patients.
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