Criteria for deep-brain stimulation in Parkinson’s disease: review and analysis
@article{Moro2006CriteriaFD, title={Criteria for deep-brain stimulation in Parkinson’s disease: review and analysis}, author={Elena Moro and Anthony E. Lang}, journal={Expert Review of Neurotherapeutics}, year={2006}, volume={6}, pages={1695 - 1705} }
Deep-brain stimulation is currently the most effective surgical treatment for advanced Parkinson’s disease. The relevant targets to date are the subthalamic nucleus and the globus pallidus internus, although the thalamus (ventralis intermedius nucleus) is preferred in tremor-dominant, aged Parkinson’s disease patients. Long-term benefit in cardinal parkinsonian signs, motor fluctuations and dyskinesia has been reported in 5-year follow-up studies of subthalamic nucleus deep-brain stimulation…
83 Citations
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Vim-DBS provides a long-term therapeutic benefit on the quality of life of tremor-dominant PD without affecting cognitive function, but cannot be recommended for non-tremor PD symptoms such as akinesia, gait disturbance, and motor fluctuation.
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- 2020
A clinical algorithm on medical management focused on the patient's phenotypic profile at the perioperative period is proposed and across the trials, the levodopa equivalent daily dose is reduced by 30 to 50% one year after surgery.
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- Biology, Psychology
- 2016
The calculation results show that the cortico-basal-thalamic network is reliable, and through the use of feasible models, high-frequency stimulation of the three targets can improve the pathological thalamic rhythmicity.
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Modulatory effects of levodopa on brain activity of the putamen during finger movement execution were showed, which were not observed with deep brain stimulation, which underlines the specificity of the findings withlevodopa treatment.
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- Medicine, PsychologyNeurology
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STN-DBS is effective beyond 15 years from the intervention, notably with significant improvement in motor complications and stable reduction of dopaminergic drugs, and despite the natural continuous progression of PD with worsening of levodopa-resistant motor and nonmotor symptoms over the years, patients undergoing STN- DBS could maintain an improvement in QoL.
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of a dissertation at the University of Miami. The current study examined cognitive effects of unilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) patients.…
Association of preoperative symptom profile with psychiatric symptoms following subthalamic nucleus stimulation in patients with Parkinson's disease.
- Psychology, MedicineThe Journal of neuropsychiatry and clinical neurosciences
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Compared with patients who improved, patients who had deteriorated behaviorally had similar prevalence and severity of preoperative behavioral symptoms but significantly shorter disease duration.
Treatment options for non-motor symptoms in late-stage Parkinson's disease
- Medicine, PsychologyExpert opinion on pharmacotherapy
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The objective of this study was to review the treatment options for Parkinson's disease dementia, psychosis, falls, bone fractures, joint and skeletal deformities, pain, orthostatic hypotension, gastrointestinal abnormalities and urological dysfunction in late-stage Parkinson's Disease.
The Instrumental Activities of Daily Living in Parkinson’s Disease Patients Treated by Subthalamic Deep Brain Stimulation
- Medicine, PsychologyFrontiers in Aging Neuroscience
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STN-DBS in PD is a safe method for improvement of everyday functioning and IADL in the post-surgery phase and lower global cognition and lower LEDD are predictive of lower I ADL in both pre-sur Surgery and post-Surgery examinations.
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