Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells.

@article{Ebert1999Cripto1IP,
  title={Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells.},
  author={Andreas D Ebert and Christian Wechselberger and Stephan Frank and Brenda Wallace-Jones and Masaharu Seno and Isabel Mart{\'i}nez-Lacaci and Caterina Bianco and Marta L De Santis and Hans K. Weitzel and David S. Salomon},
  journal={Cancer research},
  year={1999},
  volume={59 18},
  pages={4502-5}
}
Cripto-1 (CR-1), a member of the epidermal growth factor-CFC peptide family, activates the ras/raf/mitogen-activated protein/extracellular signal-regulated kinase/mitogen-activated protein kinase pathway. In the present study, the role of CR-1 in the phosphatidylinositol 3'-kinase (PI3K)/AKT (protein kinase B)/glycogen synthase kinase 3beta (GSK-3beta)-dependent signaling pathway was evaluated in human SiHa cervical carcinoma cells. Our data demonstrate that CR-1 can enhance the tyrosine… CONTINUE READING

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Cripto-1 induces phosphatidylinositol 3'-kinase - dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells .
Cripto-1 induces phosphatidylinositol 3'-kinase - dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells .
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