Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells.

@article{Bianco2002Cripto1AN,
  title={Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells.},
  author={Caterina Bianco and Heather B. Adkins and Christian Wechselberger and Masaharu Seno and Nicola Normanno and Antonella De Luca and Youping Sun and Nadia I. Khan and Nicholas Kenney and Andreas D Ebert and Kevin P. Williams and Michele Sanicola and David S. Salomon},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 8},
  pages={2586-97}
}
Cripto-1 (CR-1), an epidermal growth factor-CFC (EGF-CFC) family member, has a demonstrated role in embryogenesis and mammary gland development and is overexpressed in several human tumors. Recently, EGF-CFC proteins were implicated as essential signaling cofactors for Nodal, a transforming growth factor beta family member whose expression has previously been defined as embryo specific. To identify a receptor for CR-1, a human brain cDNA phage display library was screened using CR-1 protein as… CONTINUE READING