Cripto: a tumor growth factor and more.

  title={Cripto: a tumor growth factor and more.},
  author={E. D. Adamson and Gabriella Minchiotti and David S. Salomon},
  journal={Journal of cellular physiology},
  volume={190 3},
Cripto, a growth factor with an EGF-like domain, and the first member of the EGF-CFC family of genes to be sequenced and characterized, contributes to deregulated growth of cancer cells. A role for Cripto in tumor development has been described in the human and the mouse. Members of the EGF-CFC family are found only in vertebrates: CFC proteins in zebrafish, Xenopus, chick, mouse and human have been characterized and indicate some common general functions in development. Cripto expression was… CONTINUE READING


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