Crinophagy mechanisms and its potential role in human health and disease.

  title={Crinophagy mechanisms and its potential role in human health and disease.},
  author={Tam{\'a}s Csizmadia and G{\'a}bor Juh{\'a}sz},
  journal={Progress in molecular biology and translational science},
The Role of Deubiquitinating Enzymes in the Various Forms of Autophagy
This review focuses on the colorful role of DUBs in autophagic processes and discusses the mechanistic contribution of these molecules to normal cellular homeostasis via the possible regulation forms of autophagy mechanisms.
Epigenetic regulation of autophagy in coronavirus disease 2019 (COVID-19)
Inherent Beta Cell Dysfunction Contributes to Autoimmune Susceptibility
An overview of mitochondrial function in the beta cells is provided, potential mechanisms by which mitochondrial dysfunction may contribute to T1D pathogenesis are discussed, and there is speculation that dysfunctional mitochondrial responses could contribute to the formation of autoantigens.
Extracellular and Intracellular Factors in Brain Cancer
The dysfunction of the cell organelles and their contribution to carcinogenesis, while oncogene overexpression promotes tumorigenesis, maintenance, and progression through cell adhesion represent a fundamental requirement for cancer and its development.
Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis
A systematic review with meta-analysis was conducted, and its main goal was to reveal the multilevel connection between Alzheimer’s disease and type 2 diabetes mellitus.


Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation
Various experimental models which have been used to study mechanisms of intralysosomal degradation are discussed and the evidence obtained in support of the following proposals are discussed.
The machinery of macroautophagy
This review focuses on macroautophagy, briefly describing the discovery of this process in mammalian cells, discussing the current views concerning the donor membrane that forms the phagophore, and characterizing the autophagy machinery including the available structural information.
Pancreatic effects of ethionine: blockade of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis.
The CDE-induced pancreatic necrosis results from a sequence of events: blockade of exocytosis evolves to crinophagy and autophagy, which might lead to lysosomal activation of zymogens.
Chaperone-mediated autophagy: roles in disease and aging
Recent advances in the understanding of the molecular dynamics, regulation and physiology of chaperone-mediated autophagy are described, and the evidence in support of the contribution of CMA dysfunction to severe human disorders such as neurodegeneration and cancer is discussed.
Drosophila Arl8 is a general positive regulator of lysosomal fusion events.
Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum
Although microautophagy in mammalian cells has been traditionally considered as a form of autophagy constitutively active in the turnover of long-lived proteins, little is known about the mechanism and regulation of cargo selection.
Molecular definitions of autophagy and related processes
A panel of leading experts in the field attempts here to define several autophagy‐related terms based on specific biochemical features to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagic research.
Autophagy in the endocrine glands.
This review aims to clarify the known roles of autophagy in the physiology of the endocrine system, as well as in various endocrine diseases.
Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease.
It is observed that autophagy was specifically activated in Paneth cells from patients with CD, independently of mucosal inflammation or disease-associated variants of ATG16L1 or IRGM, and this observation might account for the disorganization of secretory granules previously reported.