Cricopharyngeal achalasia is a common cause of dysphagia in patients with mtDNA deletions.

@article{Kornblum2001CricopharyngealAI,
  title={Cricopharyngeal achalasia is a common cause of dysphagia in patients with mtDNA deletions.},
  author={Cornelia Kornblum and R. Broicher and Eric Walther and Peter Seibel and Heinz Reichmann and Thomas Klockgether and Claus Herberhold and R. K. Schroeder},
  journal={Neurology},
  year={2001},
  volume={56 10},
  pages={1409-12}
}
To assess dysphagia, the authors examined 12 patients with Kearns-Sayre syndrome (KSS) or chronic progressive external ophthalmoplegia (CPEO) due to mitochondrial DNA (mtDNA) deletion by videofluoroscopy and manometry. Cricopharyngeal achalasia was documented in nine of 12 patients (75%), whereas deglutitive coordination problems were found in one patient. Cricopharyngeal myotomy may be an effective treatment in selected cases with severe cricopharyngeal obstruction. 

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