Crick's Adaptor Hypothesis and the Discovery of Transfer RNA: Experiment Surpassing Theoretical Prediction

@article{Fry2022CricksAH,
  title={Crick's Adaptor Hypothesis and the Discovery of Transfer RNA: Experiment Surpassing Theoretical Prediction},
  author={Michael Fry},
  journal={Philosophy, Theory, and Practice in Biology},
  year={2022}
}
  • M. Fry
  • Published 30 April 2022
  • Biology
  • Philosophy, Theory, and Practice in Biology
Historically, hypotheses failed in most cases to correctly forecast the workings of complex biological systems. Francis Crick’s adaptor hypothesis, however, stands out as an exceptional case of a confirmed abstract prediction. This hypothesis presciently anticipated the existence of RNA adaptors that function as bridges between amino acids and the chemically different nucleic acid template for proteins. Crick conjectured that the adaptors are enzymatically charged with cognate amino acids, they…