Creutzfeldt-Jakob disease with plaques and paired helical filaments.

@article{Liberski1987CreutzfeldtJakobDW,
  title={Creutzfeldt-Jakob disease with plaques and paired helical filaments.},
  author={Pawel P. Liberski and Wielisław Papierz and Janusz Alwasiak},
  journal={Acta neurologica Scandinavica},
  year={1987},
  volume={76 6},
  pages={428-32}
}
A 32-year-old man with rapidly progressive dementia, pyramidal signs, myoclonic jerks and dystonic movements died following brain biopsy. neuropathological examination revealed minimal neuronal loss accompanied by mild spongiform change and astrocytic reaction. Numerous plaques and neurofibrillary tangles composed of paired helical filaments dominated the… CONTINUE READING