Creutzfeldt-Jakob Disease and eating squirrel brains

  title={Creutzfeldt-Jakob Disease and eating squirrel brains},
  author={Joseph R. Berger and Eric Robert Weisman and B Weisman},
  journal={The Lancet},


Summary Creutzfeldt–Jakob disease or CJD is characterized by rapidly progressive dementia. It also tends to cause more rapid deterioration of a person’s abilities than Alzheimer’s disease or most

Is there evidence for exogenous risk factors in the aetiology and spread of Creutzfeldt-Jakob disease?

The neurodegeneration observed in the brains of affected animals and humans is accompanied by the pathological accumulation of an aberrant form of a normal ubiquitous cell surface glycoprotein, prion protein (PrP), which is currently the most widely accepted explanation for the transmissibility of these diseases.

Using Catchment Population to Estimate Sporadic Creutzfeldt-Jakob Disease Incidence.

This annual incidence rate of sporadic Creutzfeldt-Jakob disease (sCJD) suggests that many sCJD patients are unrecognized and unreported, and the most likely explanation is enhanced clinical suspicion and improved diagnostic accuracy.

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Transmissible spongiform encephalopathies are a subset of prion misfolding diseases, specifically identified as being transmissible to other individuals in a manner resembling viral, bacterial, or toxic exposure, that have been studied in animals for decades.

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For the first time, a multiplex PCR assay was developed in Malaysia for the discriminatory identification of rat, rabbit and squirrel in the food chain and found that rat meat substitution by rat meat cannot be ruled out.

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A novel tetraplex real-time PCR assay with TaqMan probes was described to discriminate and identify all four species (cat, rabbit, rat, and squirrel) in a single assay platform and efficiency of PCR assay as well as target quantification were determined.



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The value of the thrive index below which only a minority of children fell provided a lower threshold for normality and produced a measure of the discrepancy between a child's predicted and actual growth: the “thrive index”.

Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates.

Kuru and Creutzfeldt-Jakob disease of humans and scrapie disease of sheep and goats were transmitted to squirrel monkeys (Saimiri sciureus) that were exposed to the infectious agents only by their

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Kuru established that virus infections of man could, after long delay, produce chronic degenerative disease and disease with apparent heredofamilial patterns of occurrence, and with none of the inflammatory responses regularly associated with viral infections.

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Genetic and infectious prion diseases.

Bioassays of brain extracts from two scrapie-infected Tg lines showed that the prion inoculum determines that prions are synthesized de novo, even though the cells express both PrP genes, and underscore the fundamental features of prion structure and propagation that differentiate prions from other transmissible pathogens.