Crescent, a novel chick gene encoding a Frizzled-like cysteine-rich domain, is expressed in anterior regions during early embryogenesis.

@article{Pfeffer1997CrescentAN,
  title={Crescent, a novel chick gene encoding a Frizzled-like cysteine-rich domain, is expressed in anterior regions during early embryogenesis.},
  author={Peter L Pfeffer and Edward M De Robertis and Juan Carlos Izpis{\'u}a-Belmonte},
  journal={The International journal of developmental biology},
  year={1997},
  volume={41 3},
  pages={449-58}
}
We describe the isolation of a novel chicken gene that we have termed crescent, based on the most distinctive stage of its highly dynamic expression pattern during early embryogenesis. Crescent encodes a protein that in its N-terminal half shows the characteristic invariant 9 cysteine residues of the cysteine-rich domain (CRD) found in the Frizzled family of proteins, in Smoothened and in Collagen XVIII. The CRD of several Frizzled proteins have recently been shown to bind to Wg. Unlike… CONTINUE READING

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